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Am J Physiol. 2007 Dec; 133(6):2019-28. After being discharged, he attended Temple University, where he majored in mass communication and graduated with honors. Brenner was a writer, director or producer of 115 television documentaries and headed the documentary units of Westinghouse Broadcasting and Metromedia, winning nearly 30 awards including an Emmy, before moving to comedy. J Clin Invest. J Hepatol. Am J Physiol Gastrointest Liver Physiol. 2020; 15(6):e0234038. 2003 Feb; 124(2):445-58. Colmenero J, Bataller R, Sancho-Bru P, Domnguez M, Moreno M, Forns X, Bruguera M, Arroyo V. CCR2 promotes hepatic fibrosis in mice. 1995 Jun; 21(6):303-7. Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. 2010 Jul; 139(1):323-34.e7. Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. Biochem Soc Symp. Kenji Fujiwara, MD, PhD. 2012 Nov; 143(5):1330-1340.e1. Gastroenterology. 2006 Sep; 45(3):429-38. 2001 Dec; 35(6):749-55. 2008 Sep; 5(9):496-7. 2017 09 15; 331:135-141. Jobin C, Panja A, Hellerbrand C, Iimuro Y, Didonato J. Confocal microscopy of the mitochondrial permeability transition in necrotic cell killing, apoptosis and autophagy. Achievement of optimal medical therapy goals for U.S. adults with coronary artery disease: results from the REGARDS Study (REasons for Geographic And Racial Differences in Stroke). Hepatitis C and alcohol: fundamental and translational research directions. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. J Hepatol. Liver Int. DNA Cell Biol. Current and prospective therapies for hepatic fibrosis. 2008 Jun; 118(6):2121-31. Hepatology. Second cancers after fractionated radiotherapy: stochastic population dynamics effects. Gastroenterology. 2015 Feb; 4(1):34-47. Infect Immun. 1999 Jul; 5(4):282-93. 2005 Jun; 42(6):850-9. 1998 Sep; 13(S1):S39-S50. Am J Physiol Gastrointest Liver Physiol. Schwabe RF, Bradham CA, Uehara T, Hatano E, Bennett BL, Schoonhoven R. p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver. Moderate alcohol drinking: effects on the heart and liver. J Clin Invest. 2001 May; 25(5 Suppl ISBRA):251S-253S. Hepatology. Exp Biol Med (Maywood). J Biol Chem. Hepatology. 2013 Feb; 57(2):577-89. Differential role of I kappa B kinase 1 and 2 in primary rat hepatocytes. Dig Dis. Gastroenterology. Carethers will report directly to the chancellor and is part of the leadership team. 2015 Jan; 22(1):164-73. 2004 Aug 01; 173(3):1561-70. Hepatology. 2021 07 20; 118(29). Sp1 binding activity increases in activated Ito cells. 2011 Jan 04; 108(1):308-13. Mol Ther Nucleic Acids. 2005; 23(3-4):264-74. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. 2007 Jun; 132(7):2601-4. 1997 May; 25(5):1128-35. Am J Physiol. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. 2006 Apr; 290(4):G583-9. MELD and the practicing gastroenterologist. 2021 08 01; 321(2):H435-H445. Biochim Biophys Acta. 2005 Feb; 115(2):209-18. 2022 10; 610(7931):366-372. Semin Liver Dis. Mol Biol Med. USC undermined our ability to do research. Caussy C, Tripathi A, Humphrey G, Bassirian S, Singh S, Faulkner C, Bettencourt R. Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Comparison of DNA adducts and sister chromatid exchange in lung cancer cases and controls. The future of gastroenterology and gastroenterology. Scelzo A, Di Somma S, Antonini P, Montross LP. Baeza-Raja B, Goodyear A, Liu X, Lam K, Yamamoto L, Li Y, Dodson GS, Takeuchi T. Cognitive Health of Nonagenarians in Southern Italy: A Descriptive Analysis from a Cross-Sectional, Home-Based Pilot Study of Exceptional Longevity (Cilento Initiative on Aging Outcomes Or CIAO). Acceptance Post-Bac. Wang P, Koyama Y, Liu X, Xu J, Ma HY, Liang S, Kim IH. Gastroenterology. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Mol Cell Biol. Arch Clin Biomed Res. 2019 01; 17(2):218-230. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Enomoto N, Yamashina S, Schemmer P, Rivera CA, Bradford BU, Enomoto A. IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Hepatology. Hepatology. Front Physiol. J Clin Invest. Gastroenterology. 2010 Sep; 139(3):987-98. 2023 Jan 17; 1-6. 2010 Feb 25; 3:39-47. Hepatology. 2022 08; 42(3):233-249. 2010 Jan; 30(1):31-41. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. Lehmann TG, Wheeler MD, Schwabe RF, Connor HD, Schoonhoven R, Bunzendahl H. Tumor necrosis factor alpha prevents tumor necrosis factor receptor-mediated mouse hepatocyte apoptosis, but not fas-mediated apoptosis: role of nuclear factor-kappaB. 1995 Sep; 9(9):1157-65. J Clin Invest. Sanz S, Pucilowska JB, Liu S, Rodrguez-Ortigosa CM, Lund PK. J Exp Med. 2004 Jun; 40(6):942-51. Concanavalin A-induced liver cell damage: activation of intracellular pathways triggered by tumor necrosis factor in mice. 2012; 5(Suppl 1):S17. Regulatory role of the conserved stem-loop structure at the 5' end of collagen alpha1(I) mRNA. Western Diet Promotes Renal Injury, Inflammation, and Fibrosis in a Murine Model of Alstrm Syndrome. 1997 Jan 17; 272(3):1753-60. 2014 Oct 28; 83(18):1653-60. Vasopressin inhibits type-I collagen and albumin gene expression in primary cultures of adult rat hepatocytes. 2001 Apr 10; 103(14):1920-7. Hepatology. Int J Mol Sci. Am J Physiol Gastrointest Liver Physiol. 1980 Apr 03; 302(14):765-9. 2005 Aug; 43(2):317-23. Nephron. Agreement between TOAST and CCS ischemic stroke classification: the NINDS SiGN study. 2011 Jan; 53(1):96-105. Gastroenterology. 2004 Apr; 18(6):720-2. 2007 May; 132(6):2272-5. 1998 May; 27(5):1285-95. J Gastroenterol Hepatol. 1989 May; 8(4):279-85. 2003 Jan 01; 8:d69-77. Exp Biol Med (Maywood). Gastroenterology. Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. 1988 Sep-Oct; 8(5):1040-5. Metabolic Injury of Hepatocytes Promotes Progression of NAFLD and AALD. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Gene expression profiles during hepatic stellate cell activation in culture and in vivo. Lehmann TG, Luedde T, Schwabe RF, Bunzendahl H, Samulski RJ, Lemasters JJ. Hepatology. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. Evidence for a common progenitor of epithelial and mesenchymal components of the liver. Meurer SK, Alsamman M, Sahin H, Wasmuth HE. Cell Metab. Hepatology. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. 2002 Dec; 36(6):1498-508. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. 2002 Sep; 123(3):877-8. J Immunol. J Biol Chem. J Immunol. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. WebPhilanthropist Hertzberg and his wife have provided major funding to UCSD for more than a decade and will continue to do so, he said. 2020; 15(3):e0229445. Ceramide activates the stress-activated protein kinases. Am J Physiol. Neurogastroenterol Motil. 2000 Sep 29; 275(39):30597-604. 2010 Mar; 51(3):942-52. We lose people all of the time. Yang L, Magness ST, Bataller R, Rippe RA. 1987 Dec 25; 262(36):17690-5. 2003 Nov; 112(9):1383-94. 2022 Apr 04. 2007 Apr; 132(4):1434-46. Inactivation of myofibroblasts during regression of liver fibrosis. Dr. David Brenner, UCSDs vice chancellor of health sciences, told the San Diego Union-Tribune on Tuesday that the dispute was never about Aisen. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. J Biol Chem. 1999 Aug; 14(8):1272-80. 2022 09; 609(7925):101-108. 2013 Sep; 183(3):820-30. 2003 Apr; 37(4):824-32. 1993 Apr; 264(4 Pt 1):G589-95. Long-term alcohol exposure changes sensitivity of rat Kupffer cells to lipopolysaccharide. J Clin Invest. 2019 07 23; 116(30):15184-15193. J Clin Invest. J Immunol. Hepatol Commun. J Biol Chem. Anti-fibrogenic strategies and the regression of fibrosis. J Gastroenterol. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. Proc Natl Acad Sci U S A. Blood. Itsumi M, Inoue S, Elia AJ, Murakami K, Sasaki M, Lind EF. 2003 Oct; 125(4):1009. Pharmacological inhibition of P2RX7 ameliorates liver injury by reducing inflammation and fibrosis. 2006 Nov; 291(5):G877-84. Campos Alberto E, Maclean E, Davidson C, Palikhe NS, Storie J, Tse C. Toll-like receptor 2-mediated intestinal injury and enteric tumor necrosis factor receptor I contribute to liver fibrosis in mice. Serum metabolites detect the presence of advanced fibrosis in derivation and validation cohorts of patients with non-alcoholic fatty liver disease. Hepatology. TLR4 enhances TGF-beta signaling and hepatic fibrosis. 2002 Mar; 82(3):323-33. 2014 Jun 10; 20(17):2854-72. 2017 12 21; 2(24). Impact of burn injury on hepatic TGF-beta1 expression and plasma TGF-beta1 levels. NF-kappaB stimulates inducible nitric oxide synthase to protect mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis. 1990; 14(6):639-45. Deletion of the ferrochelatase gene in a patient with protoporphyria. 2014 Dec; 26(12):1802-11. The Crosstalk between Hepatocytes, Hepatic Macrophages, and Hepatic Stellate Cells Facilitates Alcoholic Liver Disease. Uzawa K, Grzesik WJ, Nishiura T, Kuznetsov SA, Robey PG. Uehara T, Xi Peng X, Bennett B, Satoh Y, Friedman G, Currin R. In vivo pattern of lipopolysaccharide and anti-CD3-induced NF-kappa B activation using a novel gene-targeted enhanced GFP reporter gene mouse. Hepatology. 1990; 24:352-8. Madsen DH, Leonard D, Masedunskas A, Moyer A, J?rgensen HJ, Peters DE, Amornphimoltham P, Selvaraj A, Yamada SS. J Clin Invest. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. Best Pract Res Clin Gastroenterol. J Gastroenterol Hepatol. WebName Division; Curtius, Kathleen Mary: Biomedical Informatics: El-Kareh, Robert E, MD: Biomedical Informatics: Harismendy, Olivier, MD: Biomedical Informatics 1993 Feb; 17(2):287-92. Molecular mechanisms of alcohol-induced hepatic fibrosis. 2005 Jan; 54(1):134-41. WebBrenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! Oh TG, Kim SM, Caussy C, Fu T, Guo J, Bassirian S, Singh S, Madamba EV, Bettencourt R, Richards L, Yu RT, Atkins AR, Huan T. Molecular and cellular mechanisms of liver fibrosis and its regression. Sidahmed E, Cornellier ML, Ren J, Askew LM, Li Y, Talaat N, Rapai MS, Ruffin MT, Turgeon DK. 1992 May; 4(5):43-58. 1988 Apr 15; 48(8):2288-91. Ikejima K, Enomoto N, Iimuro Y, Ikejima A, Fang D, Xu J, Forman DT. 1995; 255:342-59. 2016; 7:17. Hepatology. 1990 Feb; 10(2):689-95. The focal adhesion kinase suppresses transformation-associated, anchorage-independent apoptosis in human breast cancer cells. 2005 May; 41(5):1085-95. The role of gut-derived bacterial toxins and free radicals in alcohol-induced liver injury. CCR1 and CCR5 promote hepatic fibrosis in mice. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. Gut. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. 2002 Oct; 4(5):769-81. Publisher Correction: The gut-liver axis and the intersection with the microbiome. 2008 Feb; 25(2):249-58. Recent advances in liver stem cell therapy. 2003 Mar 07; 278(10):8083-90. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. Allergy. The Role of NADPH Oxidases (NOXs) in Liver Fibrosis and the Activation of Myofibroblasts. Activation of nuclear factor-kappaB during orthotopic liver transplantation in rats is protective and does not require Kupffer cells. Next-generation academic medicine. Introducing PNAS Nexus. Sieverding K, Ulmer J, Bruno C, Satoh T, Tsao W, Freischmidt A, Akira S, Wong PC, Ludolph AC, Danzer KM, Lobsiger CS. M2-like macrophages are responsible for collagen degradation through a mannose receptor-mediated pathway. I. TNF-induced liver injury. 2008 Nov; 48(5):1420-9. Alcohol. 2008 Jul; 48(1):322-35. The fecal microbiome of ALS patients. Differential expression of the transfected liver-specific alpha 1-inhibitor III gene in normal hepatocytes and hepatoma cells in culture. Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers. Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Gastroenterology. Activation of activating protein 1 during hepatic acute phase response. 2017 12; 1(10):1043-1057. 2003 Jan 10; 278(2):927-33. 2017 May 02; 25(5):1054-1062.e5. The nicotinamide adenine dinucleotide phosphate oxidase (NOX) homologues NOX1 and NOX2/gp91(phox) mediate hepatic fibrosis in mice. 2014 Jul 21; 5:4451. 1994 Sep; 14 (9):5950-60. Clin Gastroenterol Hepatol. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Wastewater sequencing reveals early cryptic SARS-CoV-2 variant transmission. Am J Physiol. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Int Psychogeriatr. Oncogenic Ras activates c-Jun via a separate pathway from the activation of extracellular signal-regulated kinases. Biochem Biophys Res Commun. Curr Pathobiol Rep. 2014 Dec; 2(4):171-183. Pharm Res. Hepatic porphyrias. 1991 Mar; 5(3):275-81. Inhibition of transforming growth factor-beta/Smad signaling improves regeneration of small-for-size rat liver grafts. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. 2007 Apr-Jun; 6(2):83-8. 2020 Nov 03; 32(5):901. 2012 Sep; 56(3):922-32. Integr Biol (Camb). Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. Hepatology. Prolonged infusion of angiotensin II into normal rats induces stellate cell activation and proinflammatory events in liver. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? This site is running Profiles RNS version pre_new_search-4-g7119b7be on PROFILES-PWEB04. Lan T, Li C, Yang G, Sun Y, Zhuang L, Ou Y, Li H, Wang G. Modulation of the intestinal bile acid/farnesoid X receptor/fibroblast growth factor 15 axis improves alcoholic liver disease in mice. 2012 Aug; 143(2):307-20. A simplified method for the preparation of transcriptionally active liver nuclear extracts. Am J Gastroenterol. Biochem Biophys Res Commun. Am J Physiol. Klein S, Mittendorfer B, Eagon JC, Patterson B, Grant L, Feirt N. Toll-like receptor signaling in the liver. Nat Commun. Hepatology. Nuclear extract preparations, DNase I footprinting, and mobility shift assays. Myofibroblasts revert to an inactive phenotype during regression of liver fibrosis. 1995 Oct; 269(4 Pt 1):G591-9. 2015 Mar; 29(3):1043-55. FASEB J. Differentiation. Gastroenterology. 2017 10 16; 8(1):837. Liver Transpl. Fibrogenesis Tissue Repair. Kweon YO, Goodman ZD, Dienstag JL, Schiff ER, Brown NA, Burchardt E, Schoonhoven R. Akt protects mouse hepatocytes from TNF-alpha- and Fas-mediated apoptosis through NK-kappa B activation. Vice Chancellor, UC San Diego Health Sciences. Dr. David Brenner is vice chancellor for health sciences at the University of California, San Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California, San Diego, and UC San Diego Health. 2004 Feb; 24(4):1758-68. 2001 Dec; 281(6):G1357-68. 1989 May; 9(5):2224-7. Clin Gastroenterol Hepatol. 1998 Sep; 13(S1):S93-S95. Nat Med. Hum Gene Ther. J Immunol. Yang L, Bataller R, Dulyx J, Coffman TM, Gins P, Rippe RA. 1988 Jan-Feb; 8(1):176-82. Scholten D, Osterreicher CH, Scholten A, Iwaisako K, Gu G. Genetic covariance between gamma-glutamyl transpeptidase and fatty liver risk factors: role of beta2-adrenergic receptor genetic variation in twins. Tumor necrosis factor alpha in the pathogenesis of human and murine fulminant hepatic failure. Mutation of the 5'-untranslated region stem-loop mRNA structure reduces type I collagen deposition and arterial stiffness in male obese mice. Mol Cell Biol. Cell Death Differ. CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. Nucleic Acids Symp Ser. Nishiura T, Nishimura T, deSerres S, Godfrey V, Bradham CA, Nakagawa T. Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. 2012 Jun; 56(6):1283-92. Hepatology. 2006 Sep; 131(3):957-60. DNA adducts, protein adducts, and sister chromatid exchange in cigarette smokers and nonsmokers. 2018 01; 61:132-137. Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y. Molecular pathogenesis of liver fibrosis. 2008 Feb; 47(2):677-85. Interleukin-6 increases rat metalloproteinase-13 gene expression through stimulation of activator protein 1 transcription factor in cultured fibroblasts. 2001; 160:459-79. 2017 Apr 03; 127(4):1254-1270. 1999 Aug; 21(2):238-45. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. I. TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways. 1989 Feb 16; 337(6208):661-3. Gastroenterology. 1994 Jun 21; 91(13):6030-4. NFkappaB prevents apoptosis and liver dysfunction during liver regeneration.

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